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Surfactant didn't shorten ventilation in infant bronchiolitis (BESS trial)

Mar 31, 2026

~89,000 bottles of Children's Ibuprofen recalled after reports of foreign particles

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Tirzepatide cuts HbA1c by 2.23% in youth-onset type 2 diabetes

Mar 24, 2026

Federal court restores pre-January 2026 pediatric vaccine schedule

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Clinical Insights - Mar 17, 2026

Mar 17, 2026

Nearly 20,000 U.S. emergency department visits occur each year for oral prescription medication ingestions in children younger than 6 years. Clonidine and buprenorphine account for the highest hospitalization estimates.

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Clinical Insights - Mar 10, 2026

Mar 10, 2026

A 10-day hydrocortisone taper given at 14-28 days of life in ventilated preterm infants did not significantly impact functional outcomes at early school age compared with placebo.

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Clinical Insights - Mar 3, 2026

Mar 3, 2026

Six weeks of once-daily intranasal saline resolved symptoms in 29.5% of children 3-12 years old, with cumulative resolution near 50% after 12 weeks. Adding mometasone after nonresponse did not improve outcomes.

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Clinical Insights - Feb 24, 2026

Feb 24, 2026

In 44 pediatric cardiac patients 0-24 months of age (median 2.1 months), the median clopidogrel dose associated with therapeutic P2Y12 reaction unit (PRU) values was 0.22 mg/kg/day (IQR 0.19-0.34). This conflicts with the fixed 0.2 mg/kg/day recommended by the PICOLO trial.

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Clinical Insights - Feb 17, 2026

Feb 17, 2026

Explainable machine learning models achieved higher simulated therapeutic alignment than standard weight-based dosing in young children, though findings remain exploratory.

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Clinical Insights - Feb 10, 2026

Feb 10, 2026

Percentage of term and late-preterm infants who did not receive vitamin K in the U.S. increased from 2.9% to 5.2% between 2017 and 2024, with refusal trends beginning prior to the COVID-19 pandemic.

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Clinical Insights - Feb 3, 2026

Feb 3, 2026

Pediatric practice is shifting from trough-based monitoring to AUC/MIC targets of 400-600 mg·h/L, with higher initial doses and earlier monitoring to optimize exposure and reduce nephrotoxicity.

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Clinical Insights - Jan 27, 2026

Jan 27, 2026

Propranolol, esmolol, and captopril were the most commonly used agents in preterm neonates, with dosing strategies varying by gestational age and clinical stability.

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Pediatric Pearls

Clinical insights for neonatal & pediatric care.

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